-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, RGRS3Jlui1KUzyEf5Ylleew2BdPvhdqL4hbxT3RRAE3aVCDgM+u0ckYpgDs62LRO wXPlaqgGS0kd9p5FMdMdCg== 0001012975-06-000074.txt : 20060214 0001012975-06-000074.hdr.sgml : 20060214 20060213180639 ACCESSION NUMBER: 0001012975-06-000074 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20060214 DATE AS OF CHANGE: 20060213 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ARCH VENTURE FUND V LP CENTRAL INDEX KEY: 0001117120 IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: 8725 W HIGGINS RD STREET 2: STE 290 CITY: CHICAGO STATE: IL ZIP: 60631 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ALNYLAM PHARMACEUTICALS, INC. CENTRAL INDEX KEY: 0001178670 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 770602661 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-79884 FILM NUMBER: 06605525 BUSINESS ADDRESS: STREET 1: 300 THIRD STREET CITY: CAMBRIDGE STATE: MA ZIP: 02142 BUSINESS PHONE: (617) 551-8200 MAIL ADDRESS: STREET 1: 300 THIRD STREET CITY: CAMBRIDGE STATE: MA ZIP: 02142 FORMER COMPANY: FORMER CONFORMED NAME: ALNYLAM PHARMACEUTICALS INC DATE OF NAME CHANGE: 20020724 SC 13G/A 1 e8316357.txt SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2 (AMENDMENT NO. 2)* ALNYLAM PHARMACEUTICALS, INC. - -------------------------------------------------------------------------------- (Name of Issuer) COMMON STOCK - -------------------------------------------------------------------------------- (Title of Class of Securities) 02043Q107 - -------------------------------------------------------------------------------- (CUSIP Number) DECEMBER 31, 2005 - -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [_] Rule 13d-1(b) |X| Rule 13d-1(c) [_] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ARCH Venture Fund V, L.P. - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) PN - ------- ------------------------------------------------------------------------ Page 2 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ARCH V Entrepreneurs Fund, L.P. - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) PN - ------- ------------------------------------------------------------------------ Page 3 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ARCH Venture Partners V, L.P. - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON 0 WITH ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------ ------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) PN - ------- ------------------------------------------------------------------------ Page 4 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) ARCH Venture Partners V, LLC - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO - ------- ------------------------------------------------------------------------ Page 5 of 19 - ------ ------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Steven Lazarus - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A. - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN - ------- ------------------------------------------------------------------------ Page 6 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Keith Crandell - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A. - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN - ------- ------------------------------------------------------------------------ Page 7 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Robert Nelsen - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A. - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN - ------- ------------------------------------------------------------------------ Page 8 of 19 - ------- ------------------------------------------------------------------------ 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Clinton Bybee - ------- ------------------------------------------------------------------------ 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [_] (b) [_] - ------- ------------------------------------------------------------------------ 3 SEC USE ONLY - ------- ------------------------------------------------------------------------ 4 CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A. - ------- ------------------------------------------------------------------------ 5 SOLE VOTING POWER 0 NUMBER OF ----- ------------------------------------------------------ SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 1,532,697 EACH ----- ------------------------------------------------------ REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH 0 ----- ------------------------------------------------------ 8 SHARED DISPOSITIVE POWER 1,532,697 - ------- ------------------------------------------------------------------------ 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,532,697 - ------- ------------------------------------------------------------------------ 10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [_] - ------- ------------------------------------------------------------------------ 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.76% - ------- ------------------------------------------------------------------------ 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN - ------- ------------------------------------------------------------------------ Page 9 of 19 SCHEDULE 13G ------------ Item 1(a). NAME OF ISSUER: Alnylam Pharmaceuticals, Inc. (the "Issuer"). Item 1(b). ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES: 300 Third Street, Cambridge, Massachusetts 02142. Item 2(a). NAMES OF PERSONS FILING: ARCH Venture Fund V, L.P. ("ARCH Venture Fund V"); ARCH V Entrepreneurs Fund, L.P. ("ARCH V Entrepreneurs Fund"); ARCH Venture Partners V, L.P. ("AVP V LP"); ARCH Venture Partners V, LLC ("AVP V LLC") (collectively, the "Reporting Entities" and individually, each a "Reporting Entity"); and Steven Lazarus ("Lazarus"), Keith Crandell ("Crandell"), Robert Nelsen ("Nelsen") and Clinton Bybee ("Bybee") (collectively, the "Managing Directors" and individually, each a "Managing Director"). The Reporting Entities and the Managing Directors collectively are referred to as the "Reporting Persons". Item 2(b). ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE: 8725 W. Higgins Road, Suite 290, Chicago, IL 60631. Item 2(c). CITIZENSHIP: ARCH Venture Fund V, ARCH V Entrepreneurs Fund, and AVP V LP are limited partnerships organized under the laws of the State of Delaware. AVP V LLC is a limited liability company organized under the laws of the State of Delaware. Each Managing Director is a US citizen. Item 2(d). TITLE OF CLASS OF SECURITIES: Common Stock, $.01 par value (the "Common Stock"). Item 2(e). CUSIP NUMBER: 02043Q107 Item 3. IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A: None. Item 4. OWNERSHIP. (a) Amount beneficially owned: ARCH Venture Fund V is the record owner of 1,524,092 shares of Common Stock (the "ARCH Venture Fund V Shares") as of December 31, 2005. ARCH V Entrepreneurs Fund is the record owner of 8,605 shares of Common Stock (the "ARCH V Entrepreneurs Fund Shares" and, together with the ARCH Venture Fund V Shares, the "Record Shares") as of December 31, 2005. AVP V LP is the sole general partner of ARCH Venture Fund V and ARCH V Entrepreneurs Fund. AVP V LLC is the sole general partner of AVP V LP. By virtue of their relationship as affiliated entities who have overlapping general partners and managing directors, each Reporting Entity may be deemed to share the power to direct the disposition and vote of the Record Shares. As individual general partners or managing directors of each of AVP V LLC and AVP V LP, each Managing Director Page 10 of 19 may also be deemed to share the power and direct the disposition and vote of the Record Shares. (b) Percent of class: Reporting Persons: 5.76%, calculated based on 26,631,385 shares of Common Stock reported to be outstanding in the Issuer's Form 10-Q filed with the Securities and Exchange Commission on November 3, 2005. (c) Number of shares as to which the person has: (i) SOLE POWER TO VOTE OR TO DIRECT THE VOTE: 0 shares for each Reporting Person (ii) SHARED POWER TO VOTE OR TO DIRECT THE VOTE: Each of the Reporting Persons: 1,532,697 (iii) SOLE POWER TO DISPOSE OR TO DIRECT THE DISPOSITION OF: 0 shares for each Reporting Person (iv) SHARED POWER TO DISPOSE OR TO DIRECT THE DISPOSITION OF: Each of the Reporting Persons: 1,532,697 Each Reporting Person disclaims beneficial ownership of such shares of Common Stock except for the shares, if any, such Reporting Person holds of record. Item 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS. Not Applicable. Item 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON. Not Applicable. Item 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON. Not Applicable. Item 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP. Not Applicable. The Reporting Persons expressly disclaim membership in a "group" as used in Rule 13d-1(b)(ii)(J). Item 9. NOTICE OF DISSOLUTION OF GROUP. Not Applicable. Page 11 of 19 Item 10. CERTIFICATION. Not Applicable. This statement on Schedule 13G is not filed pursuant to ss.240.13d-1(b) nor ss.240.13d-1(c). Page 12 of 19 SIGNATURES ---------- After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 13, 2006 ARCH VENTURE FUND V, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------- Steven Lazarus Managing Director ARCH V ENTREPRENEURS FUND, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------- Steven Lazarus Managing Director ARCH VENTURE PARTNERS V, L.P. By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------ Steven Lazarus Managing Director Page 13 of 19 ARCH VENTURE PARTNERS V, LLC By: * ------------------------------- Steven Lazarus Managing Director * ------------------------------------ Steven Lazarus * ------------------------------------ Keith Crandell * ------------------------------------ Robert Nelsen * ------------------------------------ Clinton Bybee * By: /s/Mark McDonnell ------------------ Mark McDonnell as Attorney-in-Fact - -------------------------------------------------------------------------------- This Schedule 13G was executed by Mark McDonnell pursuant to Powers of Attorney attached hereto as Exhibit 2 and incorporated herein by reference. Page 14 of 19 EXHIBIT 1 --------- AGREEMENT --------- Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to the ownership by each of the undersigned of shares of stock of Alnylam Pharmaceuticals, Inc. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original. Dated: February 13, 2006 ARCH VENTURE FUND V, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------- Steven Lazarus Managing Director ARCH V ENTREPRENEURS FUND, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------- Steven Lazarus Managing Director ARCH VENTURE PARTNERS V, L.P. By: ARCH Venture Partners V, LLC its General Partner By: * ------------------------------ Steven Lazarus Managing Director Page 15 of 19 ARCH VENTURE PARTNERS V, LLC By: * ------------------------------- Steven Lazarus Managing Director * ------------------------------------ Steven Lazarus * ------------------------------------ Keith Crandell * ------------------------------------ Robert Nelsen * ------------------------------------ Clinton Bybee * By: /s/Mark McDonnell ------------------ Mark McDonnell as Attorney-in-Fact - -------------------------------------------------------------------------------- This Agreement was executed by Mark McDonnell pursuant to Powers of Attorney attached hereto as Exhibit 2 and incorporated herein by reference. Page 16 of 19 EXHIBIT 2 --------- POWERS OF ATTORNEY ------------------ KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Mark McDonnell his true and lawful attorney-in-fact, with full power of substitution, to sign any and all instruments, certificates and documents that may be necessary, desirable or appropriate to be executed on behalf of himself as an individual or in his capacity as a general partner of any partnership, pursuant to Sections 13 and 16 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and any and all regulations promulgated thereunder, and to file the same, with all exhibits thereto, and any other documents in connection therewith, with the Securities and Exchange Commission, and with any other entity when and if such is mandated by the Exchange Act or by the By-laws of the National Association of Securities Dealers, Inc., granting unto said attorney-in-fact full power and authority to do and perform each and every act and thing necessary, desirable or appropriate, fully to all intents and purposes as he might or could do in person, thereby ratifying and confirming all that said attorney-in-fact, or his substitutes, may lawfully do or cause to be done by virtue hereof. IN WITNESS WHEREOF, this Power of Attorney has been signed as of the 8th day of June, 2004. ARCH VENTURE FUND V, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC. its General Partner By: /s/ Keith Crandell ------------------- Managing Director ARCH V ENTREPRENEURS FUND, L.P. By: ARCH Venture Partners V, L.P. its General Partner By: ARCH Venture Partners V, LLC. its General Partner By: /s/ Keith Crandell ------------------- Managing Director ARCH VENTURE PARTNERS V, L.P. By: ARCH Venture Partners V, LLC its General Partner By: /s/ Keith Crandell ------------------- Managing Director ARCH VENTURE PARTNERS V, LLC By: /s/ Keith Crandell -------------------- Managing Director Page 17 of 19 /s/ Steven Lazarus -------------------------- Steven Lazarus /s/ Keith Crandell -------------------------- Keith Crandell /s/ Robert Nelsen -------------------------- Robert Nelsen /s/ Clinton Bybee -------------------------- Clinton Bybee Page 18 of 19 -----END PRIVACY-ENHANCED MESSAGE-----